Virological Studies in Dolphins.
Final rept. 1 Mar 69-28 Feb 71,
VARIETY CHILDREN'S RESEARCH FOUNDATION MIAMI FLA
Pagination or Media Count:
Serologic tests have disclosed that the blood of normal dolphins contains antibodies to a number of viruses infectious for man. The hemagglutination test presented no problems, but the complement fixation test was complicated by an anticomplementary activity encountered in the sera of all dolphins. This activity could be removed by precipitating the serum at low ionicity. The supernatant in these precipitates still contained antibody activity as measured by both the complement fixation and hemagglutination tests. Following experimental infection with influenza A2 an increase an in specific antibodies was demonstrated. The earliest antibody was exclusively a macroglobulin, presumably a counterpart of 19S IgM of terrestrial mammals. With passage of time, there was the appearance of a 7S antibody, presumably of the IgG type. Author