Studies on the Molluscicidal Properties of Endod '(Phytolacca dodecandra)'.
Final rept. 15 Nov 70-30 Jun 72,
STANFORD RESEARCH INST MENLO PARK CA
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Discovery of the molluscicidal properties of the natural product Endod Phytolacca dodecandra was followed by the development of a method for purification of the toxic principle and by studies to determine the chemical structure of the active principle. Butanol extraction of the aqueous suspension of the berries increases its potency by 7- to 10-fold. The extraction procedure is simple and amenable to inexpensive use in tropical areas where the plant can be grown, processed, and used as needed. The extract, which gives promise for use in control of schistosomiasis and other snail-borne diseases, remains stable under various conditions of storage, has very low mammalian oral and skin toxicities, and is not significantly affected by variations in environmental factors. Author