Pathological Lesions Caused by Methylisobuylketone,
AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OHIO
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The lesions caused by methylisobutylketone MIBK were interesting in that they were found only in one species, the rat, and in that species were limited to a specific part on one organ - the first and second sections of the proximal convoluted tubule of the nephron of the kidney. This lesion was designated hyaline droplet toxic tubular nephrosis, although in some respects it differed from the classic concept of hyaline droplet formation. The lesion was present at 14 days of exposure and continued with a variable decrease in severity throughout the exposure. In those rats removed for serial sacrifice at weekly intervals from the second week to the end of the exposure, the lesion completely reversed between the third nad fourth weeks postexposure.
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