Continuous Exposure of Animals to Methylisobutylketone,
AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OHIO
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Continuous exposure of dogs, monkeys, mice, and rats to MIBK for two weeks and all animals except mice for 90 days resulted in measurable adverse effects only in the case of rats. Rat kidney weights and kidney to body weight ratios were significantly elevated after exposure to 410 mgcu m for two weeks, and kidney and liver organ weights and organ to body weight ratios were elevated after exposure to 820 mgcu m for two weeks and to 410 mgcu m for 90 days.
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