Dichloromethane Hepatotoxicity in Mice with Continuous and Intermittent Inhalation Exposures,
AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OHIO
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Few guidelines exist for establishing acceptable exposure levels for continuous exposures to toxic substances on the basis of data obtained from single or intermittent exposure experiments. In this study, the effects of continuous inhalation of CH2Cl2 on mice were examined in detail with respect to liver changes. The effects of continuous CH2Cl2 exposures are of particular interest since CH2Cl2 is present in space cabin construction materials and may be present in trace amounts in the atmosphere of space cabins. A comparison of the effects produced by continuous exposure with those of intermittent exposures should help in extrapolating and predicting effects and results of continuous exposures from data on intermittent exposures.