Fluoride-Containing Metabolites after Methoxyflurane Anesthesia,
AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OHIO
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Methoxyflurane 2,2-dichloro-1,1-difluoroethyl methyl ether has been used for about 12 years for analgesia and anesthesia in surgery and obstetrics. Interest in methoxyflurane fluorometabolites arose when markedly elevated serum fluoride concentrations in a nephrotoxic patient were traced to the use of methoxyflurane anesthesia for surgery. These high fluoride levels were peculiar in that the ionselective fluoride electrode did not detect a substantial part of the fluoride until after its separation from the sample by the hexamethyldisiloxane-acid diffusion method. This finding suggested that inorganic fluoride F was not the only form present in the samples and that an organic acid-labile fluorometabolite OALF was also present. The objective of this research is to find out whether there are two discrete fluorometabolites, what their concentrations usually are in patients without renal failure, and whether they bear a constant relationship with each other.