Cardiopulmonary Effects of Fluorocarbon Compounds,
AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OHIO
Pagination or Media Count:
The present investigation was designed to examine the hypothesis that the cardiopulmonary toxicity of the propellants is related to the irritation of sensory receptors in the respiratory passages. The anesthetized dog was used to allow measurement of pulmonary resistance and compliance, when propellants were confined to the upper respiratory tract or were administered intratracheally, bypassing the upper respiratory tract. Additional procedures to determine whether propellants influence the bronchial smooth muscle, pulmonary blood vessels and the heart are reported. Three propellants commonly used in aerosol units containing bronchodilators were investigated. They are trichlorofluoromethane propellant 11, dichlorodifluoromethane propellant 12, and 1,2-dichloro-1,1,2,2-tetrafluoroethane propellant 114.