Accession Number:

AD0751425

Title:

Cardiac Toxicity of Aerosol Propellants,

Descriptive Note:

Corporate Author:

AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OHIO

Personal Author(s):

Report Date:

1971-12-01

Pagination or Media Count:

9.0

Abstract:

The fluoroalkane gases used to propel aerosols sensitize the hearts of mice to asphyxia-induced sinus bradycardia, atrioventricular block and T-wave depression, quickly enter the blood of monkeys, cats and dogs after inhalation and, despite adequate oxygenation, have a spectrum of cardiovascular toxic effects for example, directly depressing contractility in rat, cat, dog and human myocardium and rapidly inducing ventricular arrhythmias in awake or anesthetized monkeys. The relevance of these findings to sudden unexpected death in young people who deliberately inhale these gases, to the widespread use of household and cosmetic aerosols, which most commonly discharge as propellants, Freons 12, 11 and 114, and perhaps, to the increasing uses of other Freons e.g., the solvent, Freon 113, makes deeper study of this toxicity mandatory. Author

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE