Accession Number:

AD0751232

Title:

Effects of Monomethylhydrazine on Blood and Cerebrospinal Fluid Glucose in Anesthetized Monkeys

Descriptive Note:

Technical rept.

Corporate Author:

AIR FORCE AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OH

Report Date:

1972-06-01

Pagination or Media Count:

16.0

Abstract:

Plasma and CSF glucose was investigated in fasted, pentobarital anesthetized rhesus monkeys given monomethylhydrazine MMH 25 mgkg i.v. Glucose was determined by the glucose oxidase method. Fasting blood glucose and CSF glucose in mg averaged 48.8 plus or minus 2.5 S.E. and 45.1 plus or minus 2.9 S.E. respectively. The CSFblood ratio of 0.923 is similar to that reported for dogs but differs from the ratio of 0.6 for humans. Following MMH, both blood and CSF glucose increased to 90.6 plus or minus 8.0 and 63.8 plus or minus 5.5 mg respectively and the CSFblood ratio decreased to 0.704. Formation of CSF averaged 0.028 and 0.035 mlmin before and after MMH respectively. Convulsions occurred in half the monkeys 120 minutes after MMH, a time when both blood and CSF glucose were elevated.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE