Selective Reductions via Hydrides.
Final rept. 1 Jul 66-30 Jun 72,
PURDUE RESEARCH FOUNDATION LAFAYETTE IND
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The syntheses, modifications, and chemistry of sodium borohydride and lithium aluminum hydride have been investigated. Research has made it possible to prepare a wide variety of alkyl substituted borohydrides, LiR3BH. These are the most powerful and highly stereoselective reducing agents now available to organic chemists. These have been used in the total synthesis of prostaglandins. Research has opened up a detailed exploration of chloroboranes. These derivatives react rapidly with olefins to produce dialkylboron chloride in excellent yield. Author
- Organic Chemistry