Penetration of the Intestinal Epithelium by Various Microorganisms
WALTER REED ARMY INST OF RESEARCH WASHINGTON DC
Pagination or Media Count:
Enteric microbes may be classified into four groups in accordance with their invasive potential into the host. The first group is characterized by a pathogen which readily invades through the epithelial barrier, multiples in the mucosa and leads to a systemic invasion. Salmonella organisms belong to this group. The second group is represented by shigella dysentery. Shigella organisms characteristically produce far more severe epithelial changes than salmonellae. Members of the third group preferentially reside in the brush border and may or may not produce an overt acute inflammatory response and structural alterations of the gut mucosa. This group includes Cryptosporidium wrairii, and intestinal spirochetes attaches to the gut epithelium but causes severe symptoms thru absorption of their moiety. This group is exemplified by cholera vibrio. The report summarizes observations on the host-microbe interaction at the epithelial barrier in the first three types of enteric infections.