Control of VEE Epizootic-Epidemic by Vaccine Developed at USAMRIID
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
Pagination or Media Count:
Venezuelan equine encephalomyelitis VEE is a zoonotic arbovirus disease affecting both Equidae and man. Infection in equine animals may be subclinical, but more often it assumes one of the following clinical forms a mild illness consisting primarily of anorexia, fever, and depression b severe illness characterized by anorexia, high fever, stupor, staggering, and blindness, followed by recovery with or without permanent sequellae or c fatal disease with a similar sequence of signs, but terminating in death. Overall mortality rate in equines probably exceeds 75 of those infected. In man, VEE commonly occurs as an influenza-like illness characterized by generalized muscular pains, severe frontal headache and high fever overt signs of encephalitis are rare, occurring primarily in children. Overall mortality in humans probably is no more than 1. As part of the effort to control these epidemics a live attenuated virus vaccine TC-83 developed at the U. S. Army Medical Research Institute of Infectious Diseases USAMRIID was administered to horses, burros, and mules. The TC-83 vaccine was originally developed for protection of laboratory personnel working in high-risk areas and subsequently has been administered to more than 6,000 human beings. During developmental studies, evidence suggested that the vaccine might be suitable for use in Equidae.
- Animal Husbandry and Veterinary Medicine
- Medicine and Medical Research