A Mediator for Triggering Non-Specific Host Defense Mechanisms,
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD
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Prospective clinical studies in volunteers have shown that experimentally-induce bacterial or viral infections induce alterations early in the prodromal period in a variety of anabolism-related metabolic processes. Studies in experimental animals and man have shown that the mechanisms leading to these host changes were mediated by an endogenous humoral factor which enters the serum. This heat labile endogenous mediator, like endogenous pyrogen, was released by PMN leukocytes and possibly other cells after the initiation of a generalized infection. Endogenous mediator may prove to be a key intermediate in stimulation of various non-specific host defense mechanisms.
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