The Effect of Folate on Abnormal Carbohydrate Metabolism,
ARMY MEDICAL RESEARCH AND NUTRITION LAB DENVER COLO
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It has been demonstrated that certain human glycolytic and one gluconeogenic enzymes showed adaptive changes in activity with dietary carbohydrate or pharmacologic doses of folic acid. Physiologic amounts of the vitamin did not cause as great a change in enzyme activity as was seen with pharmacologic doses of folate 1 mgday or more and the changes began within one hour and reached a maximum by 18 to 24 hours. The mechanism whereby folate caused this adaptive response is not known. These adaptive changes in enzyme activity occurred both in the jejunum and liver of rats. It is speculated that the human hepatic glycolytic enzymes might be affected similarly to the human jejunal enzymes. If this were so, then pharmacologic doses of folate might be useful to treat patients with a deficiency of fructose-1-phosphate aldolase hereditary fructose intolerance or fructose-1,6-diphosphatase which causes a hypoglycemic syndrome. The use of folate in the treatment of two naturally occurring enzyme deficiency diseases and studies concerning the effect of ethanol-induced enzyme deficiency states is described.
- Anatomy and Physiology
- Medicine and Medical Research