Trimethoprim-Sulphamethoxazole in Acute Brucellosis
NAVAL MEDICAL RESEARCH UNIT NO 3 FPO NEW YORK 09527
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Eight patients with proved brucella infection were treated with trimethoprim-sulphamethoxazole. The dose varied from two to four tablets given twice daily for three weeks. Clinical response was rapid and all patients were asymptomatic and afebrile within two to seven days of starting therapy. Three patients relapsed clinically and bacteriologically within three weeks of ending treatment. It is suggested that the treatment be continued for at least six weeks to prevent relapses.