Accession Number:

AD0750113

Title:

Penetration of Pyridinium Oximes into Human Red Blood Cells.

Descriptive Note:

Technical rept. Jan 70-Jan 72,

Corporate Author:

EDGEWOOD ARSENAL MD

Personal Author(s):

• Ellin,Robert I.
• Groff,William A.
• Sidell,Frederick R.

Report Date:

1972-09-01

Pagination or Media Count:

17.0

Abstract:

Pralidoxime, a water-soluble monoquaternary oxime, penetrates red cells in relatively high concentrations, both in vitro and in vivo. Structurally related bisquaternary oximes, toxogonin and TMB-4, do not enter to an appreciable extent. Penetration is due to the molecular volume and charge of the oxime, rather than to lipid solubility. Author

Descriptors:

• (*OXIMES
• *ERYTHROCYTES)
• HUMANS
• PENETRATION
• MOLECULAR PROPERTIES
• DRUGS
• CELLS(BIOLOGY)
• PHARMACOLOGY

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE