Accession Number:

AD0750113

Title:

Penetration of Pyridinium Oximes into Human Red Blood Cells.

Descriptive Note:

Technical rept. Jan 70-Jan 72,

Corporate Author:

EDGEWOOD ARSENAL MD

Report Date:

1972-09-01

Pagination or Media Count:

17.0

Abstract:

Pralidoxime, a water-soluble monoquaternary oxime, penetrates red cells in relatively high concentrations, both in vitro and in vivo. Structurally related bisquaternary oximes, toxogonin and TMB-4, do not enter to an appreciable extent. Penetration is due to the molecular volume and charge of the oxime, rather than to lipid solubility. Author

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE