Penetration of Pyridinium Oximes into Human Red Blood Cells.
Technical rept. Jan 70-Jan 72,
EDGEWOOD ARSENAL MD
Pagination or Media Count:
Pralidoxime, a water-soluble monoquaternary oxime, penetrates red cells in relatively high concentrations, both in vitro and in vivo. Structurally related bisquaternary oximes, toxogonin and TMB-4, do not enter to an appreciable extent. Penetration is due to the molecular volume and charge of the oxime, rather than to lipid solubility. Author