Accession Number:

AD0749455

Title:

Uptake and Retention of Adenine Moiety by Stored Human Red Blood Cells.

Descriptive Note:

Interim rept.,

Corporate Author:

ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Report Date:

1972-06-30

Pagination or Media Count:

16.0

Abstract:

The adenine moiety, which is utilized by the red cells for net synthesis of various nucleotides, does not appear to be in a steady-state equilibrium between plasma and erythrocytes. As storage time increases, the equilibrium is shifted towards the red cells and reached a maximum radioactive content at 21 days. After this time a reversal occurs. At the beginning of storage the association of adenine with erythrocytes is not very strong, since the radioactive material can be removed to a great extent by saline extraction. The retention increases with length of storage and attains a maximum value at 21 days. Specific association of the radioactive label has been observed with cell populations of low density young cells. Author

Subject Categories:

  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE