Behavior, Ecology and Toxicity of Venomous Marine Fishes.
Rept. no. 22 (Quarterly technical) 1 Jul-30 Sep 72,
PROFESSIONAL STAFF ASSOCIATION OF LAC/USC MEDICAL CENTER LOS ANGELES CALIF
Pagination or Media Count:
The present experiments were designed to define the hemodynamic alterations produced by the venom of S. guttata in the dog. The effects of atropine upon the action of venom were studied in three dogs. The effects of venom upon systemic venous return were studied in two open chest dogs. In animals pretreated with atropine the initial arterial hypotension is inhibited and the number and severity of ECG changes are reduced. The arterial hypotension produced by S. guttata venom represents a distributive defect in circulating blood volume which may be due to the release of endogenous acetylcholine. The venom causes the release of acetylcholine in vitro, and the hemodynamic changes are reminiscent of those produced by the injection of acetylcholine. The effects of venom upon the packed cell volume, return of blood to the right heart, and the appearance of the spleen at necropsy may be due in part to splenic constriction, with its consequent autotransfusion of venous blood with a high red cell mass. Author