Morphologic Studies of Hepatitis.
Annual summary rept. 22 Sep 71-22 Sep 72,
MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
Pagination or Media Count:
Particles were found in cases of chronic hepatitis in hepatocellular nuclei, and these were identified as Australia antigen HB Ag by its ability to combine with ferritin labelled HB antibody. The relation of HB Ag to hepatitis has been postulated to be related to the response of the host to an antigen composed in large part of the hosts own protein. Two animal models were studied. One was galactosamine induced hepatitis, in which the ultrastructural details of orotate protection was investigated, and the second was alpha naphthyliocyanate induced cholestasis, in which the bile acid pattern and the relation of jaundice to the development of peripheral cholestasis were elucidated. Author
- Medicine and Medical Research