Effect of Lipogenin on Fatty Acid Synthesis in the Liver of Irradiated Rats.
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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The effect of a factor, named lipogenin, on the activity of the fatty acid synthesizing liver enzyme system of rats exposed to 1200 rads of x rays or of mixed neutron-gamma radiation has been investigated in this study. Catalytic amounts of lipogenin extracted from yeast were added to cell-free liver preparations obtained from x irradiated rats. The increased rate of fatty acid synthesis in these irradiated rats was considerably decreased after the addition of lipogenin. Addition of the same amount of lipogenin to liver homogenates from rats exposed to mixed neutron-gamma radiation caused a slight increase of lipogenesis which is damaged by this radiation. Endogenous liver lipogenin extracted from livers of x irradiated rats was found to maintain its activity, whereas material extracted from animals exposed to mixed neutron-gamma radiation was inactive. Experimental evidence in this study indicates that, in all probability, lipogenin acts at the fatty acid synthetase level of the fatty acid synthesizing liver enzyme system. The implications of these findings are discussed. Author