Accession Number:

AD0748967

Title:

Cell Kinetics Simulation in the Treatment of Acute Granulocytic Leukemia,

Descriptive Note:

Corporate Author:

RAND CORP SANTA MONICA CALIF

Personal Author(s):

Report Date:

1972-03-01

Pagination or Media Count:

11.0

Abstract:

The use of medical information for clinical decisionmaking and the use of formal computer-based methodologies which can critically improve patient management in leukemia and in solid tumors are explored. The aim of the scientific treatment of disease is to intervene as directly as possible in the biology of the disease process. But as medical therapy penetrates deeper into this fundamental biology, the more numerous become the circumstances where a therapeutic plan must be instituted or a therapy sustained on the basis of indirect evidence. This is particularly true of treatments involving the use of powerful pharmacological agents. Some successful mathematical models of patient response to treatment have been developed, however, which demonstrably improve the clinical management of patients. Systems of models simulating patient response to cancer chemotherapy are discussed.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE