The Effects of Scopolamine upon Spontaneous Wheel Running,
TEXAS TECH UNIV LUBBOCK CENTER OF BIOTECHNOLOGY AND HUMAN PERFORMANCE
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The data presented revealed that the scopolamine injected prairie dogs ran significantly less revolutions than the saline injected or control animals. This indicated that the 0.5 mgkg injection of scopolamine suppressed spontaneous running in the activity wheel. The decrease in activity seems to be contradictory to Payne and Andersons 1967 findings, however the higher dosage used by Payne and Anderson could possibly account for these differences. However, these results are consonant with the findings of Bradley and Elkes 1957 and Richard Moore 1971 which suggest that scopolamine acts in a sedative manner on the CNS. The results also indicated that the increase in wheel running seen when scopolamine is paired with intracranial stimulation is not due to an arousal effect of the drug.