OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
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Bradykinin is inactivated when any one of its eight peptide bonds is cleaved. The term kininase was coined when the structure of kinins was still unknown, although enzymes should obviously not be named after a single substrate. It indicates the existence of an enzyme capable of inactivating bradykinin. Kininases are widely distributed in nature. Their sources range from human blood to bacteria. The two enzymes discussed are kininase I or carboxypeptidase N and kininase II or peptide dipeptide hydrolase.