Studies Concerning the High Pressure Hyperexcitability in the Squirrel Monkey.
Final rept. 1 Apr 69-31 Mar 72,
WRIGHTSVILLE MARINE BIO-MEDICAL LAB WILMINGTON N C
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Development of knowledge on the high pressure neurological syndrome HPNS in vertebrates is described on the basis of five years of investigative effort. Besides tracing the historical sequence of events, the report details experimentation aimed at providing a basis for predicting the onset of severe HPNS complications in man at various compression rates ranging from those in current use for cautions descent of subjects seeking to reach maximum depths to the very fast compression rates contemplated in relation with submarine escape techniques. A variety of other data concerning the HPNS are reviewed briefly from the points of view of their bearing upon design of prophylactic or therapeutic procedures, formulation of questions requiring additional clinical exploration, and elucidation of basic biophysical mechanisms. Attention is called to the fact that the underlying mechanisms seem to be common not only to all vertebrates tested, but to a rather similar sequence elicited by high pressures in many invertebrates. Problems of adaptation and of selection for individual variation are touched upon. Author
- Stress Physiology