Accession Number:

AD0745284

Title:

Alteration of Radiation Effects by 2-(n-Decylamino) Ethanethiosulfuric Acid (WR1607) in the Monkey

Descriptive Note:

Scientific rept.

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Personal Author(s):

• Turbyfill, C. L.
• Roudon, R. M.
• Young, R. W.
• Kieffer, V. A.

Report Date:

1972-03-01

Pagination or Media Count:

25.0

Abstract:

2-n-decylamino ethanethiosulfuric acid WR 1607 was given to trained and untrained monkeys 10 mgkg 30 minutes prior to irradiation to investigate its effects on behavior and physiology during the early transient incapacitation period. The trained monkeys were trained to perform a shock motivated visual discrimination task. Following the injection of WR1607 a significant increase occurred in aortic pressure with a significant decrease in heart rate. No significant changes in percent correct trials or latency occurred following injection. After irradiation the respiratory rate increased significantly in all injected groups. Trained injected monkeys irradiated with a pulse of 2500 or 4000 rads did not display a decrease in performance during the early incapacitation period 0-20 minutes postirradiation. Trained monkeys not receiving the drug displayed a decrease in performance below a 90 percent correct response level in both the 2500- and 4000-rad groups. The physiology and behavior of treated and untreated animals were not significantly different after the first 20-minute postirradiation period.

Descriptors:

• *RADIOPROTECTIVE AGENTS
• PHYSIOLOGY
• BEHAVIOR
• DRUGS
• IN VIVO ANALYSIS
• RADIATION EFFECTS
• BIOASSAY
• MONKEYS
• RADIATION INJURIES
• ATTENUATION
• RADIATION DOSAGE

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE