Hemoglobin Function in Stored Blood: XII. Effects of Varying Phosphate Concentrations on Red Cell ATP and 2,3-DPG with Adenine and Inosine.
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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Adenine in a concentration of 2 mM was most effective for maintaining 2,3-DPG and ATP levels under the conditions of the study. When the preservative contained adenine and inosine the highest concentrations of phosphate, 6 mM and 8 mM, maintained both ATP and 2.3-DPG better during the first two weeks however, during the third week the intermediate concentration of phosphate, 4 mM, seemed to be as good or better than all other preservatives for maintaining 2,3-DPG and ATP. After three weeks of storage there appeared to be little difference between preservatives with respect to maintaining 2,3-DPG although ATP was better maintained in both the adenine and the adenine plus inosine preservatives containing high phosphate concentrations. Author
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