Thermal Destruction of Anti-A1 and Anti-A(A2) from Group O and Group B Serum.
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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The study has demonstrated that DEAE fractionated IgG anti-A from group O and group B serum could be converted to anti-A1. The rate of conversion for fractionated IgG was not as rapid as serum, a fact that is consistent with documented thermostability properties of IgG. Scientific literature has suggested that the conversion of anti-A to anti-A1 may have a practical application in blood banking operations, i.e., differentiation of group A from A subgroups. Evidence from this study leads to the conclusion that the ABO type and thus the immunoglobulin consistency of serum from that type is not as significant as 1 the original anti-A titer and 2 the magnitude of the difference between the anti-A1 and anti-AA2 when seeking an antiserum that will not appreciably denature while retaining those properties which enable it to convert to anti-A1 specificity. Author
- Anatomy and Physiology