Platelet Aggregation Produced by Collagenolysis Product Peptides,
CHILDREN'S HOSPITAL WASHINGTON D C BIOCHEMICAL RESEARCH LAB
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Saline solutions of about 1 microgram of each of seven of the eight collagen peptides released by the action of cutaneous collagenase upon soluble collagen were capable of affecting the aggregation of platelets. Thus, at least two important cellular responses to injury i.e., PMN infiltration and platelet aggregation can be demonstrated to be produced by the products of collagenolysis. These findings on platelet aggregation reinforce the relative importance of collagenolysis product peptides in the overall process of inflammation.