Accession Number:

AD0744829

Title:

Acute Toxicity in Rats and Mice Resulting from Exposure to HCl Gas and HCl Aerosol for 5 and 30 Minutes

Descriptive Note:

Final rept.

Corporate Author:

SYSTEMED CORP DAYTON OH

Personal Author(s):

• Darmer, Jr., K. I.
• Kinkead, E. R.
• DiPasquale, L. C.

Report Date:

1972-04-01

Pagination or Media Count:

23.0

Abstract:

Rats and mice have been subjected to HCl vapor and HCl aerosol for periods of 5 and 30 minutes to determine the acute toxicity of HCl. To simulate as nearly as possible the exposure conditions at rocket engine test firing sites, HCl vapor was mixed with a saturated water droplet mist in a Longley exposure chamber to obtain HCl aerosol atmospheres. The results indicate that HCl vapor and HCl aerosol have comparable toxicity in rats and mice, respectively. The results of the present study were compared to those obtained in another study of HCl vapor toxicity in rabbits and guinea pigs, and it was found that HCl had the same degree of toxicity in mice, rabbits, and guinea pigs, while rats were considerably more tolerant to the effects of HCl.

Descriptors:

• *HYDROCHLORIC ACID
• AEROSOLS
• RATS
• VAPORS
• TOXICITY
• RABBITS
• COMBUSTION PRODUCTS
• TOXIC TOLERANCES
• GUINEA PIGS
• GASES
• EXPOSURE(PHYSIOLOGY)
• MICE
• ROCKETS

Subject Categories:

• Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE