Accession Number:

AD0744455

Title:

A Sequential Ultrastructural Study of the Effects of an Intravenous Lipid Emulsion,

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH AND NUTRITION LAB DENVER COLO

Personal Author(s):

• Demaree,Richard S. , Jr.
• Senger,Phillip L.
• Bischoff,Marshall B.
• Jones,Lloyd D.

Report Date:

1972-04-01

Pagination or Media Count:

24.0

Abstract:

Rabbits received 20cckg of intravenous lipid emulsion and were terminated from 2 hours to 8 weeks post-injection. Pigment became prominent at 6 days and was still present in liver and spleen at 8 weeks. Lipid was incorporated into macrophages in spleens at 2 hours by endocytosis. By 6 days this lipid was surrounded by pigment. The pigment was morphologically identical to secondary lysosomes. These results suggest that this lipid emulsion once incorporated into lysosomes of liver and spleen is stored there. Author

Descriptors:

• *LIPIDS
• CELLS(BIOLOGY)
• BIOLOGICAL ABSORPTION
• LIVER
• RETICULOENDOTHELIAL SYSTEM
• HISTOLOGY
• CYTOLOGY
• SPLEEN
• VISUAL INSPECTION
• RABBITS
• EXPERIMENTAL DATA

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE