Accession Number:

AD0744052

Title:

The Development of L Phase Variants of 'Neisseria meningitidis and their Pathogenicity in Experimental Animals.

Descriptive Note:

Annual rept. 1 Oct 72-30 Sep 73,

Corporate Author:

CHICAGO UNIV ILL

Personal Author(s):

• Bohnhoff,Marjorie A.
• Morello,Josephine A.

Report Date:

1972-05-18

Pagination or Media Count:

20.0

Abstract:

The frequency of transformation to L forms among 119 isolates of Neisseria meningitidis was found to be greatest in strains of serotype Boshard Y. Sixty per cent of Boshard isolates showed a rate of transformation of 1 L form10 to the 6th power diplococci, an incidence characteristic of reverted L form strains. Comparison of isolates from blood, spinal fluid and nasopharynx demonstrated that strains cultured from blood, particularly from patients without meningitis, had the highest potential for L form transformation. L form transformation has been demonstrated among 39 of 45 fresh clinical isolates of N. gonorrhoeae including direct isolation of wall-deficient gonococci from cutaneous lesions. The rate of transformation was much higher than that found for meningococcal strains, with the greatest frequency occurring among cervical isolates. Author

Descriptors:

• *NEISSERIA MENINGITIDIS
• NEISSERIA GONORRHOEAE
• BACTERIA
• GENETICS
• STABILITY
• PATHOLOGY
• INFECTIOUS DISEASES
• CULTURE MEDIA
• GROWTH(PHYSIOLOGY)
• RESISTANCE(BIOLOGY)
• ENZYMES
• DEOXYRIBONUCLEIC ACIDS

Subject Categories:

• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE