The Development of L Phase Variants of 'Neisseria meningitidis and their Pathogenicity in Experimental Animals.
Annual rept. 1 Oct 72-30 Sep 73,
CHICAGO UNIV ILL
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The frequency of transformation to L forms among 119 isolates of Neisseria meningitidis was found to be greatest in strains of serotype Boshard Y. Sixty per cent of Boshard isolates showed a rate of transformation of 1 L form10 to the 6th power diplococci, an incidence characteristic of reverted L form strains. Comparison of isolates from blood, spinal fluid and nasopharynx demonstrated that strains cultured from blood, particularly from patients without meningitis, had the highest potential for L form transformation. L form transformation has been demonstrated among 39 of 45 fresh clinical isolates of N. gonorrhoeae including direct isolation of wall-deficient gonococci from cutaneous lesions. The rate of transformation was much higher than that found for meningococcal strains, with the greatest frequency occurring among cervical isolates. Author