Hemoglobin G Hsi-Tsou: Beta 79 Asp yields to Gly
NAVAL MEDICAL RESEARCH UNIT NO 2 MANILA (PHILIPPINES)
Pagination or Media Count:
Hb G Hsi-Tsou was found in Taiwan, in 1964, in two chinese sisters who were born in Hipei Province. Structure analyses now have shown that the anomaly in this variant is at the beta-79 or beta EF3 position where a glycyl group replaces the aspartyl group normally present at that location. Another hemoglobin variant found in Chinese subjects, Hb G Taichung, previously has been reported to have the structure change Asp yields to His at the corresponding location in the alpha chain, position alpha EF3 or alpha-74. In the index case separations of the hemoglobin fractions by chromatography with DEAE-Sephadex column revealed that the relative amounts of Hbs Ao and G Hsi-Tsou were 54 and 46, respectively. Presence of HbG Hsi-Tsou in the Heterozygote apparently causes no anemia.