Accession Number:

AD0743713

Title:

Agonist-Antagonist Interaction at the Cholinergic Receptor of Denervated Diaphragm,

Descriptive Note:

Corporate Author:

DEFENCE STANDARDS LABS MARIBYRNONG (AUSTRALIA)

Personal Author(s):

Report Date:

1971-12-22

Pagination or Media Count:

14.0

Abstract:

A study has been made of the cholinergic receptor induced by chronic denervation in the rat diaphragm. The agonists acetylcholine, carbachol and tetramethylammonium produced a dose-dependent contraction of the denervated diaphragm. These agonists also brought about a graded depolarization of the muscle cells. Supramaximally effective doses of agonists caused desensitization of the preparation however, there was no cross tachyphylaxis between acetylcholine and carbachol. Author

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE