Interrelation of Systemic and Cellular Responses to Acute and Chronic Hypoxia.
Final rept. 1 Jan 63-31 Dec 70,
NORTH CAROLINA UNIV CHAPEL HILL
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A number of separate, though interrelated projects are described in this report. They are grouped into two major categories - 1 the effects of hypoxia on cell metabolism, and 2 the effects of hypoxia on behavior. One of the major objectives was a study of certain features of the process of acclimation to simulated high altitude. This included a the effects of altitude acclimation on cellular metabolic and behavioral responses to acute hypoxia, b the effects of altitude acclimation on one of the enzymes important to anaerobic metabolism latic dehydrogenase and on the relative vascularity of brain, heart and skeletal muscle, c the adaptive value of two of the prominent changes observed at altitude hyperventilation and polycythemia, and d an attempt to determine the stimulus responsible for the increased vascularity of organs in altitude-acclimated animals. Author
- Stress Physiology