Wound Healing and Cellular Microenvironment
Final technical rept. 1970-1971
CAMBRIDGE UNIV (UNITED KINGDOM)
Pagination or Media Count:
Investigations of oxygen supply to dermal and epidermal elements in healing tissue have been made with oxygen electrodes in rabbit ear window preparations and in human subjects. Effects of mild stress and hemorrhagic and endotoxic shock on wound environment have been measured with oxygen, pH, and carbon dioxide electrodes a new micro carbon dioxide electrode is described. Development of a laser flash technique for measuring diffusion of oxygen in tissue is described. Studies have been initiated on the effects of anticollagen antibodies on fibroblasts in order to examine their possible role in the slow healing of burns. Oxygen applied directly to healing surfaces is likely to speed epidermal healing, and wound dressings that exclude atmospheric oxygen are likely to slow epidermal healing. The development of hemorrhagic or endotoxic shock delays wound healing because vessels in a damaged area are especially liable to perfusion failure and to leakage. Treatment of shock by intravenous infusion of fluids of low colloid osmotic pressure may well worsen the local environment of a wound.
- Anatomy and Physiology