Accession Number:

AD0743174

Title:

Drug Absorption: Some Mathematical Considerations

Descriptive Note:

Technical rept. May 1971-Aug 1971

Corporate Author:

EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s):

• Sidell, Frederick R.

Report Date:

1972-05-01

Pagination or Media Count:

10.0

Abstract:

Using the absorption equation of Wagner and Nelson and the integrated form of the equation describing the plot of plasma concentration versus time, formulas were derived which may be helpful in comparing rates of drug absorption. The percentage absorbed over a specified time period and the time required for absorption to be 25, 50, 75, or 99 complete can be readily calculated if it is assumed the basic equations are valid.

Descriptors:

• *DRUGS
• MATHEMATICAL MODELS
• FREQUENCY
• PHYSIOLOGY
• BIOLOGICAL ABSORPTION
• INJECTIONS(MEDICINE)
• INGESTION(PHYSIOLOGY)

Subject Categories:

• Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE