Accession Number:

AD0743062

Title:

Effect of Increasing Doses of Ionizing Radiation on Liver Enzymes Involve in Fatty Acid Synthesis

Descriptive Note:

Scientific rept.

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Personal Author(s):

• McHale, C. G.
• Catravas, G. N.

Report Date:

1972-03-01

Pagination or Media Count:

23.0

Abstract:

The effect of increasing doses of x rays and of mixed neutron-gamma radiation on the fatty acid synthesizing liver enzyme system in rats has been investigated. It was found that the activity of this enzyme system first increased with radiation dose and then decreased in rats exposed to either x rays or mixed neutron-gamma radiation. Acetyl CoA carboxylase activity was found to be more sensitive to mixed neutron-gamma radiation decreased than to x rays, whereas fatty acid synthetase appeared to be more sensitive to x rays increased than to mixed neutron-gamma radiation.

Descriptors:

• *ENZYMES
• *FATTY ACIDS
• *LIVER
• *RADIATION EFFECTS
• BIOSYNTHESIS
• CARBOXY LYASES
• EXPERIMENTAL DATA
• GAMMA RAYS
• NEUTRONS
• RADIATION DOSAGE
• RATS
• X RAYS

Subject Categories:

• Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE