Accession Number:

AD0742577

Title:

Sporidesmins. Part XII. Isolation and Structure of Sporidesmin G, a Naturally-Occurring 3,6-Epitetrahiopiperazine-2,5-Dione,

Descriptive Note:

Corporate Author:

NATIONAL RESEARCH COUNCIL OF CANADA HALIFAX (NOVA SCOTIA) ATLANTIC REGIONAL LAB

Personal Author(s):

• Francis,E.
• Rahman,R.
• Safe,S.
• Taylor,A.

Report Date:

1971-08-16

Pagination or Media Count:

4.0

Abstract:

When the tail fractions from chromatograms of sporidesmin E I n3 were rechromatographed, a new crystalline metabolite of Pithomyces chartarum was isolated with molecular formula C18H20ClN3O6S4. The new compound, named, sporidesmin G I n4, gave sporidesmin I n2 on irradiation of treatment with triphenylphosphine, and sporidesmin D V after reduction and methylation. It was shown that the model compound, 1,4-dimethyl-3,6-epidithiopiperzine-2,5-dione, gave the cyclic tetraulphide on treatment with dihydrogen disulphide. Similarly, sporidesmin and sporidesmin E when treated with dihydrogen disulphide gave the new metabolite. Author

Descriptors:

• (*FUNGI
• *CHROMATOGRAPHIC ANALYSIS)
• METABOLISM
• ORGANIC SULFUR COMPOUNDS
• MOLECULAR STRUCTURE
• NITROGEN HETEROCYCLIC COMPOUNDS
• SYNTHESIS(CHEMISTRY)
• AMIDES
• CANADA

Subject Categories:

• Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE