Accession Number:
AD0742574
Title:
The Crystal Structure of Lidocaine Hydrohexafluoroarsenate,
Descriptive Note:
Corporate Author:
NATIONAL RESEARCH COUNCIL OF CANADA OTTAWA (ONTARIO) BIOCHEMISTRY LAB
Personal Author(s):
Report Date:
1971-06-15
Pagination or Media Count:
8.0
Abstract:
Crystals of lidocaine 2-diethylamino-2, 6-acetoxylidide hydrohexafluoroarsenate, C14H23N2OAsF6 are monoclinic, and were observed and measured diffractometrically. The crystal structure was determined by heavy-atom methods and refined by block-diagonal least-squares to a final R index of 0.044. The lidocaine moiety was found to be in the biologically active cationic form, with the amino nitrogen atom protonated. This atom is strongly hydrogen-bonded to the oxygen atom of an adjacent cation. Pairs of such bonds join pairs of cations across centres of symmetry. The amido nitrogen atom is weakly hydrogen-bonded to a fluorine atom of the hexafluoroarsenate anion. Author
Descriptors:
Subject Categories:
- Pharmacology
- Crystallography
- Atomic and Molecular Physics and Spectroscopy