Accession Number:

AD0742574

Title:

The Crystal Structure of Lidocaine Hydrohexafluoroarsenate,

Descriptive Note:

Corporate Author:

NATIONAL RESEARCH COUNCIL OF CANADA OTTAWA (ONTARIO) BIOCHEMISTRY LAB

Personal Author(s):

Report Date:

1971-06-15

Pagination or Media Count:

8.0

Abstract:

Crystals of lidocaine 2-diethylamino-2, 6-acetoxylidide hydrohexafluoroarsenate, C14H23N2OAsF6 are monoclinic, and were observed and measured diffractometrically. The crystal structure was determined by heavy-atom methods and refined by block-diagonal least-squares to a final R index of 0.044. The lidocaine moiety was found to be in the biologically active cationic form, with the amino nitrogen atom protonated. This atom is strongly hydrogen-bonded to the oxygen atom of an adjacent cation. Pairs of such bonds join pairs of cations across centres of symmetry. The amido nitrogen atom is weakly hydrogen-bonded to a fluorine atom of the hexafluoroarsenate anion. Author

Subject Categories:

  • Pharmacology
  • Crystallography
  • Atomic and Molecular Physics and Spectroscopy

Distribution Statement:

APPROVED FOR PUBLIC RELEASE