Accession Number:

AD0742445

Title:

Characterization of Tissue Ingrowth Into Porous Bioceramics

Descriptive Note:

Technical no. 2, Sep 1971-Apr 1972

Corporate Author:

CLEMSON UNIV SC DIV OF INTERDISCIPLINARY STUDIES

Report Date:

1972-05-01

Pagination or Media Count:

137.0

Abstract:

A study of the tissue compatibility of the aluminum oxide implant material under different stress conditions in rabbits was performed over 4- and 8-week implantation periods. The specific objectives was to examine endosteal bone ingrowth into aluminum oxide cone-shaped stump plugs in amputated tibiae, while additional peelet-shaped implants in the tibiae and femur of rabbits with amputated and non-amputated limbs were studied to determine a if the degree of loading placed on the amputated limb was sufficient to promote bone activity, b the degree of inertness andor toxicity of the aluminum oxide implants, and c a possible cause of bone spurs. The results of the radiographic, histologic and microradiographic analyses of the in vivo implants demonstrated that there was little mineralized bone ingrowth into the cone-shaped aluminum oxide implants in the amputated tibiae. The study also showed that the aluminum oxide pellet implants in the tibiae and femur of the non-amputated limbs demonstrated excellent mineralized bone ingrowth into surface and internal pores.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE