Characterization of Tissue Ingrowth Into Porous Bioceramics
Technical no. 2, Sep 1971-Apr 1972
CLEMSON UNIV SC DIV OF INTERDISCIPLINARY STUDIES
Pagination or Media Count:
A study of the tissue compatibility of the aluminum oxide implant material under different stress conditions in rabbits was performed over 4- and 8-week implantation periods. The specific objectives was to examine endosteal bone ingrowth into aluminum oxide cone-shaped stump plugs in amputated tibiae, while additional peelet-shaped implants in the tibiae and femur of rabbits with amputated and non-amputated limbs were studied to determine a if the degree of loading placed on the amputated limb was sufficient to promote bone activity, b the degree of inertness andor toxicity of the aluminum oxide implants, and c a possible cause of bone spurs. The results of the radiographic, histologic and microradiographic analyses of the in vivo implants demonstrated that there was little mineralized bone ingrowth into the cone-shaped aluminum oxide implants in the amputated tibiae. The study also showed that the aluminum oxide pellet implants in the tibiae and femur of the non-amputated limbs demonstrated excellent mineralized bone ingrowth into surface and internal pores.
- Medicine and Medical Research