Interferon Inducing Properties of Certain Strains of Tick-Borne Encephalitis Virus (Interferonogennye Svoistua Nekotorykh Shtammov Virusa Lkeshchevogo Entsefalita)
ARMY FOREIGN SCIENCE AND TECHNOLOGY CENTER CHARLOTTESVILLE VA
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The study of the correlation between the production of interferon and the multiplication of tick-borne encephalitis TE in mice in relation to the degree of pathogenicity of viruses, routes of their inoculation and the temperature of maintenance of inoculated animals has shown that a highly pathogenetic strain, S of M, of virus TE with any method of inoculation stimulated the production of a large quantity of the interferon in the brain of mice while, with the inoculation of a weakly pathogenetic strain, S of K, a large quantity of interferon is in the brain only with the intracerebrum inoculation of the virus. An increase of temperature of maintenance of the mice to 35 degrees led to a certain acceleration of viral reproduction and the accumulation of interferon even though the maximum titres of that and the other fell off equal to the control and the test.