Accession Number:

AD0742056

Title:

Interferon Inducing Properties of Certain Strains of Tick-Borne Encephalitis Virus (Interferonogennye Svoistua Nekotorykh Shtammov Virusa Lkeshchevogo Entsefalita)

Descriptive Note:

Corporate Author:

ARMY FOREIGN SCIENCE AND TECHNOLOGY CENTER CHARLOTTESVILLE VA

Personal Author(s):

Report Date:

1971-11-10

Pagination or Media Count:

12.0

Abstract:

The study of the correlation between the production of interferon and the multiplication of tick-borne encephalitis TE in mice in relation to the degree of pathogenicity of viruses, routes of their inoculation and the temperature of maintenance of inoculated animals has shown that a highly pathogenetic strain, S of M, of virus TE with any method of inoculation stimulated the production of a large quantity of the interferon in the brain of mice while, with the inoculation of a weakly pathogenetic strain, S of K, a large quantity of interferon is in the brain only with the intracerebrum inoculation of the virus. An increase of temperature of maintenance of the mice to 35 degrees led to a certain acceleration of viral reproduction and the accumulation of interferon even though the maximum titres of that and the other fell off equal to the control and the test.

Subject Categories:

  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE