Passive Suppression Characteristics of a Rabbit Antihuman Lymphocyte Serum.
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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The passive suppression characteristics of a rabbit antihuman lymphocyte serum of high titer anti-B.L., resulting from prolonged immunization with purified lymphocytes from a single individual, B.L., were studied. This antiserum had been shown to contain antibodies directed primarily against a human species lymphocyte antigen however, the antibodies appeared to have a broadened specificity which cross-reacted with individual-specific antigens. Antibodies directed solely toward individual-specific human lymphoid antigens could not be detected. It was found that anti-B.L. could suppress not only the immune response to B.L. lymphocytes, but similarly suppressed the immune response to non-B.L. lymphocytes from each of two other individuals unrelated to B.L., and to each other. Author
- Medicine and Medical Research