Accession Number:

AD0741381

Title:

Coagulation and Hemostatic Effects of Dextran and Other Macromolecules.

Descriptive Note:

Rept. no. 2 (Final comprehensive), 1 Oct 68-30 Sep 71,

Corporate Author:

NEW YORK BLOOD CENTER N Y

Personal Author(s):

Report Date:

1972-04-06

Pagination or Media Count:

32.0

Abstract:

A major problem associated with the use of several colloids as plasma substitutes for blood replacement, blood volume expansion, resuscitory and other therapeutic purposes, is hemostatic failure in a certain percentage of human as well as animal recipients, first documented for dextran D by Crosby et al 1. This serious disadvantage has been similarly observed with several related and non-related macromolecular agents -- hydroxyethyl starch HES, polyvinyl pyrrolidone PVP, acacia, some of gelatin -- and, indeed, with large volumes of bank blood. The causes of the hemostatic defect remains obscure. The objective was helping elucidate the underlying cause of this hemostatic failure. Author

Subject Categories:

  • Medicine and Medical Research
  • Medical Facilities, Equipment and Supplies

Distribution Statement:

APPROVED FOR PUBLIC RELEASE