Coagulation and Hemostatic Effects of Dextran and Other Macromolecules.
Rept. no. 2 (Final comprehensive), 1 Oct 68-30 Sep 71,
NEW YORK BLOOD CENTER N Y
Pagination or Media Count:
A major problem associated with the use of several colloids as plasma substitutes for blood replacement, blood volume expansion, resuscitory and other therapeutic purposes, is hemostatic failure in a certain percentage of human as well as animal recipients, first documented for dextran D by Crosby et al 1. This serious disadvantage has been similarly observed with several related and non-related macromolecular agents -- hydroxyethyl starch HES, polyvinyl pyrrolidone PVP, acacia, some of gelatin -- and, indeed, with large volumes of bank blood. The causes of the hemostatic defect remains obscure. The objective was helping elucidate the underlying cause of this hemostatic failure. Author
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