Accession Number:

AD0738654

Title:

Treatment of Experimental Cerebral Edema.

Descriptive Note:

Final rept. 1 Jun 66-31 May 69,

Corporate Author:

PRESBYTERIAN-ST LUKE'S HOSPITAL CHICAGO ILL DEPT OF PATHOLOGY

Personal Author(s):

Report Date:

1971-12-01

Pagination or Media Count:

75.0

Abstract:

The edema associated with hemorrhagic cerebral lesions produced by focal freezing in subhuman primates rhesus monkeys was studied by quantitative chemical methods. This research involved measuring not only the hemispheric water, potassium, sodium, chloride, and iron, but also the uptake of I.V. administered Evans blue and iodinated I131 serium albumin. The effects of systemic hypothermia and of hypotension were studied. The conclusion was that this form of edema could be effectively treated by either method, but that the former was the more effective. Because the state of hypothermia was associated with moderate hypotension, and vice versa, the beneficial effects could not be attributed to either factor acing alone. The experimental model was compared to human disease, and therapeutic recommendations for clinical conditions were made. Author

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE