Dynamics of Immune Response in Mice Following Administration of Pertussis Monovaccine,
FORT DETRICK FREDERICK MD
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Mice infected with pertussis meningoencephalitis showed no correlation between the blood agglutinin level and specific resistance. Single immunization with corpuscular pertussis vaccine caused a weak production of agglutinins, mainly of immunoglobulin M during which 80 of the mice were resistant to intracerebral pertussis bacillus infection. Double immunization of mice with pertussis vaccine sharply stimulated antibody synthesis basically immunoglobulin G, during which the level of specific resistance either decreased or remained essentially unchanged, possibly due to the organism s sensibilization. Highly toxic doses of pertussis vaccine caused more intensive synthesis of antibodies by the mice, but they died from pertussis intoxication during the presence of many antibodies in the blood. Mice of the C57BL strain highly sensitive to intracerebral infection by pertussis bacillus as a result of vaccination acquired highly specific resistance, but less sensitive CBA strain mice did not acquire sufficient resistance.
- Medicine and Medical Research