Thermoinactivation of Viruses. Announcement 2. On the Nature of Abnormalities in the Dynamics of Viral Inactivation
FORT DETRICK FREDERICK MD
Pagination or Media Count:
The mechanism was studied of the origin of dynamic inactivation irregularities of the viruses of the Venezuelan Equine Encephalitis VEE, which are formed at 50-55 degrees in the first weeks and months after reproduction. The heterogeneity of the viral population is based on the described phenomenon. The t sup r variant of VEE, isolated from the initial population, was characterized by significant delta Npr95.4 kilocaloriemole, deltaSpr219.4 E.E. and deltaNnk26.02 kcmole, deltaSnk8.15 E.E. At 52-56 degrees, the t sup r variant of VEE was inactivated in contrast to the initial strain by the nuclein type that also caused an inactivation dynamics disturbance. The disappearance of the phenomenon after viral incubation at 4 degrees was related to a lowered stability in these conditions of the t sup r viral variant and to its gradual disappearance from the viral population.