Behavior, Ecology and Toxicity of Venomous Marine Fishes.
Quarterly technical rept. no. 19, 1 Oct-31 Dec 71,
PROFESSIONAL STAFF ASSOCIATION OF LAC/USC MEDICAL CENTER LOS ANGELES CALIF
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A series of studies on the in vitro neutralization of Scorpaena guttata venom with antivenins prepared against the venoms of the stonefish Synanceja trachynis and the scorpionfish S. porcus were carried out. The antivenins were prepared in the conventional manner that is, by giving successively increasing doses of the crude venom to horses over a 17-week period, maintaining the horse on a maintenance dose for three weeks, then drawing off designated amounts of blood for processing. The stonefish antivenin provided little protection against the lethal activity of S. guttata venom. Only at 1.0 ml of antivenin per ml of venom was there any seemingly significant protection. The S. porcus gave some protection at the 0.20 level, the 0.50 level and the 1.00 level. At the last level the amount of venom required for the LD50 had increased threefold. It is apparent that there is some significant cross-protection between the antivenins of these two Scorpaena species. Further immunochemical work is in progress on the venoms of four Scorpaena species.
- Biological Oceanography