Optimal Regulation of Physiological Systems via Real-Time Adaptive Model Synthesis
STANFORD UNIV CA STANFORD ELECTRONICS LABS
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Optimal control algorithms that use an adaptive non-recursive digital filter model for on-line closed-loop blood pressure regulation have been developed. This Automatice Therapeutic Control System was designed specifically for the regulation of physiological systems, but the design assumptions are such that it should prove very useful for a much broader class of control problems. An Adaptive Model Control system has been developed, the analysis of which is presented in two parts 1 the real-time adaptive model synthesis procedure, and 2 the optimal forward-time controller. The Adaptive modeling process is accomplished by the rapidly converging Alpha-LMS Algorithm. The conditions necessary to guarantee convergence for deterministic inputs are presented for zero mean and nonzero mean additive-output noise system and also for the low- order approximation problem. The optimal forward-time controller is described. The results of an experimental run are included in which these algorithms were used to regulate the blood pressure of a dog that had been artificially placed in a hypotensive state shock. The results of this and similar experiments have been very successful from both an engineering and medical point of view, and if the necessary arrangements can be made with the local hospitals, this system will be used in the near future as part of an intensive care unit.
- Biomedical Instrumentation and Bioengineering