Accession Number:

AD0735515

Title:

Inhibition by Thyrocalcitonin (Calcitonin) of the Cyclic AMP-Mediated Stimulation of Thymocyte Proliferation by Epinephrine,

Descriptive Note:

Corporate Author:

NATIONAL RESEARCH COUNCIL OF CANADA OTTAWA (ONTARIO) DIV OF BIOLOGY

Personal Author(s):

• Whitfield,J. F.
• MacManus,J. P.
• Gillan,D. J.

Report Date:

1970-12-03

Pagination or Media Count:

5.0

Abstract:

Epinephrine stimulates the proliferation of rat thymic lymphocytes maintained in vitro by a cyclic AMP-mediated process. The mitogenic action of epinephrine is completely inhibited by low concentrations 6.0 to 8.0 mU per ml of a highly purified sample of porcine thyrocalcitonin calcitonin. In view of the fact that the same low levels of thyrocalcitonin are known to inhibit the cyclic AMP-mediated mitogenic action of vasopressin and the similar physiologically important mitogenic action of parathyroid hormone, it is proposed that thyrocalcitonin calcitonin may be general regulator of cyclic AMP-controlled cell proliferation in vivo. Author

Descriptors:

• *THYROID HORMONES
• *EPINEPHRINE
• MITOSIS
• MITOSIS
• CELLS(BIOLOGY)
• THYMUS
• ADENOSINE PHOSPHATES
• METABOLISM
• CELL DIVISION
• PARATHYROID HORMONES
• CARDIOVASCULAR AGENTS

Subject Categories:

• Biochemistry
• Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE