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Accession Number:
AD0735515
Title:
Inhibition by Thyrocalcitonin (Calcitonin) of the Cyclic AMP-Mediated Stimulation of Thymocyte Proliferation by Epinephrine,
Descriptive Note:
Corporate Author:
NATIONAL RESEARCH COUNCIL OF CANADA OTTAWA (ONTARIO) DIV OF BIOLOGY
Report Date:
1970-12-03
Pagination or Media Count:
5.0
Abstract:
Epinephrine stimulates the proliferation of rat thymic lymphocytes maintained in vitro by a cyclic AMP-mediated process. The mitogenic action of epinephrine is completely inhibited by low concentrations 6.0 to 8.0 mU per ml of a highly purified sample of porcine thyrocalcitonin calcitonin. In view of the fact that the same low levels of thyrocalcitonin are known to inhibit the cyclic AMP-mediated mitogenic action of vasopressin and the similar physiologically important mitogenic action of parathyroid hormone, it is proposed that thyrocalcitonin calcitonin may be general regulator of cyclic AMP-controlled cell proliferation in vivo. Author
Distribution Statement:
APPROVED FOR PUBLIC RELEASE