Effects of Altitude on Cellular Metabolism and Terminal Oxidation.
Rept. no. 3 (Final), 15 Apr 68-30 Jun 71,
HOWARD UNIV WASHINGTON D C DEPT OF PHYSIOLOGY
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The program was concerned with a study of the cellular metabolic effects of altitude exposure, particularly in relation to energy metabolism. The experimental conditions employed 18,000 or 25,000 feet exposure for 6-7 days resulted in hypaphogia, weight loss, increased hematocrit, increased plasma pyruvate and plasma lactate. The hypophagic response indicated the need to include a food control group in these studies as well as a normal control. Altitude exposure did not alter cytochrome oxidase activity of kidney, liver, or heart mitochondria. Mitochondrial oxidative phophorylation was not imparied in liver or kidney mitochondria. Most significantly the respiratory capacity of kidney metochondria was markedly decreased in response to altitude exposure. Histological studies revealed pulmonary congestion, liver glycogen depletion, and increased adrenal cortical cytochrome oxidase activity occurring in altitude exposure. Author
- Hygiene and Sanitation